alizapride hydrochloride
Alizapride hydrochloride
CAS: 59338-87-3
Molecular Formula: C16H22ClN5O2
alizapride hydrochloride - Names and Identifiers
alizapride hydrochloride - Physico-chemical Properties
| Molecular Formula | C16H22ClN5O2 |
| Molar Mass | 351.83118 |
| Melting Point | 206-208° |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Pale Beige |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | Alizapride has an N-allyl moiety, N-deallyl and/or epoxidation reactions may occur, and chemically reactive metabolites are expected to form. |
| In vivo study | Alizapride is not toxic in mice and rats (especially in parenteral administration). Alizapride is mainly excreted as unmodified drug after oral or parenteral administration; However, about 25% of Alizapride undergoes metabolic transformation before it is excreted. In rats, alizapril (5 mg/kg, I. V.) antagonized the abovementioned dose of Apomorphine-induced reduction in gastrointestinal motility. |
alizapride hydrochloride - Preparation Method of aripiprazole hydrochloride
from titanium academic
Application (patent) number:
CN200710042059.7
application date:
2007-06-15
Public/Announcement Number:
CN101066968B
Public/announcement date:
2012.11.07
applicant (patent):
Shanghai Bosu Pharmaceutical Technology Co., Ltd.
inventor:
Zhang Guangming , Sun Leda , Shen Xiao-wen
National and provincial code:
CN310104
Abstract:
The present invention relates to a preparation method of aripiprazole hydrochloride, comprising the steps of:(1) preparation of intermediate 2-methoxy-4-amino-5-nitrobenzoic acid;(2) preparation of intermediate 2-methoxy-4-acetamido-5-nitrobenzoic acid sodium salt;(3) preparation of intermediate 2-methoxy-4, 5-diaminobenzoic acid;(4) preparation of intermediate 5-methoxy-6-carboxybenzotriazole;(5) preparation of intermediate 5-methoxy-6-methoxycarbonylbenzotriazole;(6) preparation of aripiprazole hydrochloride. The invention has the advantages of high yield, simple operation and less pollution.
Last Update：2024-01-02 23:10:35
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